Katawa Shoujo (lit. “Cripple Girls”) is a visual novel that was developed by Four Leaf Studios, an “international team of amateur developers”. Based on a sketch by doujinshi Raita Honjou (who’s also the character artist for Valkyria Chronicles), the game takes place in a high school for disabled teenagers. 4 years in development, Katawa Shoujo was released early this year and the team disbanded soon after.
I haven’t played it, but most of the comment threads about the game seem to start with someone wondering out loud whether it’s as perverted and exploitative as it sounds, to be answered by fans who claim the subject matter is treated tastefully and that the actual sex, which is minimal, takes a backseat to the development of the characters and their relationships.