The basic idea behind the original Karoshi was completely counter-intuitive to most games: in every level you must FIND A WAY TO KILL YOURSELF. It was harder than it seemed!
In Karoshi 2.0, creator Jesse Venbrux extends that metaphor across 42 more levels, creating some of the most LOL-worthy and mind-bending puzzles I have ever seen. This is a true battle between Man and Game, and Game is using every trick up its sleeve. Prepare to have your head messed with (sometimes literally). I love it!
Karoshi 2.0 also comes with a level editor and a timed version of the original game (minus the irritating blood splatters on the screen that obscured the playfield).
(Source: Auntie Pixelante, the awesome new games blog from dessgeega)